The mission of the Translational Core is to generate new laboratory discoveries about neurodevelopment that can be rapidly and safely translated to the clinical research and clinical care delivery settings in MIDB. We accomplish this goal by
- Forming cross-disciplinary teams of clinical and pre-clinical faculty to ensure scientific information flows from the research lab to the patient bedside and back
- Educating clinical and pre-clinical faculty via courses and seminars
- Implementing seed grants to foster pre-clinical research and demonstrate proof-of-concept
Phu Tran, PhD
Department of Pediatrics
How We Engage
Examples of Engagement
Hosting of the United States Developmental Origins of Health and Disease Society
The leadership of the Translational Core will be hosting the annual meeting of the United States Developmental Origins of Health and Disease Society from October 9-11, 2022. The main theme is “Environmental Exposures: Assessment Methodologies, Mechanisms, and Health Outcomes”. Learn more about the United States Developmental Origins of Health and Disease Society.
Supporting Development of Treatment for Iron Deficiency Anemia
Iron deficiency (ID) anemia is the foremost micronutrient deficiency worldwide, affecting around 40% of pregnant women and young children. ID during the prenatal and early postnatal periods has a pronounced effect on neurodevelopment, resulting in acute deficits in early life, and more importantly, long-term effects such as cognitive impairments and increased risk for neuropsychiatric disorders. The MIDB Translational team demonstrated in preclinical models appropriate timing of choline supplementation can rescue some of these long-term effects (e.g., improved learning and memory). These findings were a basis for a clinical trial where choline supplementation was used to mitigate the neurocognitive impairments of children exposed to alcohol in utero (FASD). Learn more about the trial.