General and clinical interventions are driven by the extensive groundwork of many bench scientists and translational researchers. The MIDB's scientific cores comprise numerous labs, institutes, and research centers collaborating to better the brain health of children.
The mission of the Masonic Institute for the Developing Brain’s (MIDB) Analytics Core is to support data analytics and statistics across a broad array of research activities relevant to brain health and brain development. The Core accomplishes its mission via: 1) Consultation, 2) development of statistical methods, and 3) hands on computational work. The core also works closely with the Data Informatics Core to make developed tools and resources available to the broader community to facilitate research related to MIDB’s mission.
Community Integration and Education
The primary mission of the Measurement and Human Phenotyping (MAP) Core is to support the clinical research community. Anchoring this mission is the fundamental observation that adaptive and maladaptive functioning that define psychiatric and neurodevelopmental disorders is first and foremost determined by cognitive and behavioral assessment. The MAP core has assembled a team of experts to 1) optimize clinical, developmental, and experimental assessment of research participants; 2) train researchers on state-of-the-art and/or gold standard clinical, developmental, and experimental assessments; 3) execute clinical, developmental, and experimental assessments for research studies; 4) manage and cultivate continued expansion of research participant registries; 5) integrate and iterate with the informatics, neuroimaging, and neuromodulation cores to ensure effective synthesis across the units; and 6) establish a Biomarker Consultative Committee, constituted by key experts around campus but external to MIDB to ensure that MIDB investigators are leveraging the broader expertise of the University community as needed.
The mission of the MIDB Informatics Core is to support data acquisition, management, and interpretation needs across a broad array of research activities relevant to brain health. Our guiding principle is that significant advances in brain health can only be made by harmonizing data across multiple large data sets.
The Core accomplishes its mission via: 1) Consultation; 2) Development of standardized data acquisition, processing, harmonization, and organization methods; 3) Aggregation, integration, and dissemination of basic, applied, clinical, and pre-clinical science data for MIDB stakeholders and collaborators. The Core works closely with other University of Minnesota informatics experts and individuals specializing in research and clinical care to facilitate research related to MIDB’s mission.
The mission of the translational core is to generate new laboratory discoveries about neurodevelopment that can be rapidly and safely translated to the clinical research and clinical care delivery settings in MIDB. The members of this core are involved in the flow of scientific information from "bench to bedside" and are responsive to research agendas driven from clinical care.
The mission of Intervention Core of the Masonic Institute for the Developing Brain is to seek foundational knowledge about the developing brain and nervous system and to apply that knowledge towards integrated interventions that optimize pediatric outcomes, for a lifetime.
To support this mission, the intervention core:
1) Conducts research to advance pediatric outcomes through valuable scientific discoveries in pediatric health and care.
2) Develops novel cutting-edge interventions such as neuromodulation.
3) Promotes the experience and backgrounds of a diverse team of experts for the individual care and development of the optimal intervention for each child.